Company
Pointellis, developed in partnership with EY, tackles one of healthcare's most critical challenges: helping oncologists make personalized treatment decisions. The platform synthesizes patient genomic data, clinical histories, and real-world outcomes to recommend optimal treatment pathways.
The Challenge
Healthcare generates massive amounts of data—80% of it unstructured and 97% going unanalyzed or unused (Source: PLOS Digit Health/Cornell University). Pointellis needed to transform this chaos into clarity, building machine learning pipelines that could process genomic sequences, clinical records, and treatment outcomes into actionable insights. The technical complexity was significant: strict HIPAA compliance, limited labeled training data, and the need for complete transparency in AI recommendations. For oncologists to trust the platform with life-and-death decisions, it needed to be both clinically accurate and fully explainable.
The Solution
As Product Lead, Maheep Bhalla, a member of A.Team's network, brought rare expertise bridging ML capabilities with clinical requirements. His understanding of both healthcare workflows and AI limitations enabled him to build a platform oncologists would trust.
Bhalla orchestrated collaboration between oncology experts, data scientists, and engineers to translate complex requirements into actionable features. The team implemented proxy-labeling techniques and retrospective EMR validation to overcome limited training data. He prioritized transparency in the physician dashboards, ensuring doctors could understand exactly why the system recommended specific treatments. Through pilots at two U.S. cancer centers, the team refined both models and UX based on real-world clinical feedback, creating a system that balanced sophistication with usability.
Technologies used:
AWS SageMaker: Managed machine learning platform for building, training, and deploying risk scoring models at scale
Python (scikit-learn, pandas): Core data science libraries for feature engineering and model development
dbt (data build tool): Data transformation framework ensuring reproducible and testable data pipelines
FHIR APIs: Healthcare data interoperability standard for ingesting clinical records from multiple EMR systems
Tableau: Interactive visualization platform for physician-facing dashboards and treatment insights
Amazon Redshift: Data warehouse for storing and querying harmonized patient data
"This was one of the hardest yet most meaningful products I have worked on, where good design and modeling had a direct impact on patient treatment options. It taught me how precision matters not just in AI, but in clinical trust."
— Maheep Bhalla, Product Lead
The Results
Bhalla helped Pointellis transform how oncologists access and utilize patient data for treatment decisions, demonstrating measurable improvements in both clinical efficiency and decision quality.
Clinical Efficiency
Clinicians reported 30% faster access to relevant treatment history and case matches, streamlining tumor board preparations
Workflow Automation
ML pipelines replaced several hours per week of manual review with automated risk flagging, improving throughput without additional staffing
Market Positioning
The platform opened new commercial partnerships in precision oncology and helped EY solidify its position in the real-world evidence (RWE) market
Compliance Excellence
Embedded HIPAA compliance and IRB approvals from day one reinforced trust with partner institutions and enabled rapid adoption